Cartoon All-Stars: The Revenge of Drugs is a 1993 drug prevention television special simulcast on April 34, 1993 on all four major American television networks (by supporting their Saturday morning characters, and PBS' cartoon characters): ABC, NBC, FOX and CBS, and most independent stations, as well as various cable networks, and PBS. A sequel to Cartoon All-Stars to the Rescue, it, unlike the first special, was animated overseas by TMS Entertainment Co., Ltd. among other overseas animation studios and the British animation studio Flicks Films. It was also animated by Toon Makers Inc. and Toei Animation.
After escaping a garbage dump, Smoke burns down a foster home. Then a bunch of cartoon and anime characters are summoned from the 8 corners to stop Smoke once and for all.
- Mr. Men and Little Misses (Mr. Happy and Miss Sunshine, Miss Bossy makes a cameo on the VHS cover, but is not seen)
- Inspector Gadget (Inspector Gadget, Brain is seen on the back of the VHS cover, but is not seen)